张孝进 材化学院 MACROMOL RAPID COMM, JAN 2017. A Functionalized Cyclic Lactide Monomer for Synthesis of Water-Soluble PolyLactic Acid and Amphiphilic Diblock PolyLactic Acid

A Functionalized Cyclic Lactide Monomer for Synthesis of Water-Soluble PolyLactic Acid and Amphiphilic Diblock PolyLactic Acid

Zhang, Xiaojin;Dai, Yu*

MACROMOLECULAR RAPID COMMUNICATIONS

Volume 38, Issue 2,January 2017

DOI:10.1002/marc.201600593

Abstract:

Biodegradable and bioabsorbable poly(lactic acid)s are one of the most important biomedical materials. However, it is difficult to introduce the functional groups into poly(lactic acid)s in order to improve their hydrophilicity and degradation rate. Here the authors describe the synthesis of functionalized cyclic lactide monomer3,6-bis(benzyloxymethyl)-1,4-dioxane-2,5-dione (BnLA) using an advanced synthetic route. Water-soluble hydroxyl-functionalized homopoly(lactic acid) (P(OH)LA) is synthesized via ring-opening polymerization (ROP) of BnLA, followed by a hydrogenolytic deprotection reaction. Amphiphilic diblock poly(lactic acid) (P(OH)LA-PLA) is synthesized via ROP of DL-lactide using PBnLA as an initiator, followed by a hydrogenolytic deprotection reaction. P(OH)LA-PLA is able to form polymeric micelles with the diameter of sub-100 nm.全文链接